Ohio Key is an island in the lower Florida Keys.
U.S. 1 (or the Overseas Highway) crosses the key at approximately mile marker 39, between Missouri Key and Bahia Honda Key.
It was once known as Little Duck Key, however the name Little Duck Key is currently used for a very small island about a mile east that is the western terminus of the Seven Mile Bridge.
Today it is also known as Sunshine Key, after a camping resort located there.
The portion of the island south of US Route 1 is protected as the Ohio Key National Wildlife Refuge.